Ketamine: A Safe & Effective Treatment

Over the past 20 years and in dozens of studies, ketamine has been shown to produce remarkably fast antidepressant effects. As a result, it has become a life-changing treatment for many suffering from treatment-resistant depression and anxiety.

Ketamine is used in hospitals daily. Over the last 50 years, doctors have discovered multiple uses for ketamine in mental health conditions. In fact, the evidence is so strong the American Psychiatric Association put out a statement saying that the antidepressant effects of ketamine are both rapid and robust.

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Clinical Research

Anxiety

Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy

JOURNAL OF PSYCHOACTIVE DRUGS

Abstract:

The unique experience that ketamine facilitates with its biological, experiential, and psychological impacts has been tailored to optimize office-based treatment evolving into a method that we call Ketamine Assisted Psychotherapy (KAP). This article is the first to explore KAP within an analytical framework examining three distinct practices that use similar methods. Here, we present demographic and outcome data from 235 patients. Our findings suggest that KAP is an effective method for decreasing depression and anxiety in a private practice setting, especially for older patients and those with severe symptom burden.

Depression

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

AMERICAN JOURNAL OF PSYCHIATRY

Abstract:

Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.

Obsessive-Compulsive Disorder

Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept

AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY

Abstract:

Those receiving ketamine (n=8) reported significant improvement in obsessions (measured by OCD-VAS) during the infusion compared with subjects receiving placebo (n=7). One-week post-infusion, 50% of those receiving ketamine (n=8) met criteria for treatment response (≥35% Y-BOCS reduction) vs 0% of those receiving placebo (n=7). Rapid anti-OCD effects from a single intravenous dose of ketamine can persist for at least 1 week in some OCD patients with constant intrusive thoughts.

Mood Disorders

Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Abstract:

According to patients' reports, very low dose sub-lingual (VLDS) ketamine produced rapid, clear and sustained effects, improving mood level and stability, cognition and sleep in 20 patients (77%), with only mild and transient light-headedness as a common side-effect (no euphoria, psychotic or dissociative symptoms). Remission remained in some patients after stopping ketamine.

PTSD (Posttraumatic Stress)

A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder

AMERICAN JOURNAL OF PSYCHIATRY

Abstract:

The ketamine group showed a significantly greater improvement in CAPS-5 and MADRS total scores than the midazolam group from baseline to week 2. At week 2, the mean CAPS-5 total score was 11.88 points (SE=3.96) lower in the ketamine group than in the midazolam group (d=1.13, 95% CI=0.36, 1.91). Sixty-seven percent of participants in the ketamine group were treatment responders, compared with 20% in the midazolam group. This randomized controlled trial provides the first evidence of efficacy of repeated ketamine infusions in reducing symptom severity in individuals with chronic PTSD.

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